Horizon Europe’s 2025 draft Cluster 1 Health Work Programme – any call topic of interest to you?
25th February 2025 at 3:58 pm
Horizon Europe: research & innovation for a healthier future
European funding for European health research and innovation (R&I) is crucial for tackling major public health challenges. Through Horizon Europe, the EU’s flagship funding programme, researchers and innovators gain access to essential resources to contribute to the EU’s health priorities. With 8.3 billion euros allocated to Pillar 2, Cluster 1: Health for the period 2021-2027, the funding opportunities under Horizon Europe play an important role in tackling current societal health challenges and ensuring a healthier future for all.
Unlocking the future: Draft insights on the Horizon Europe 2025 Work Programme
With the draft Health Work Programme 2025 already available online, it is time to start planning resources and putting consortia together for successful submissions later this year. Although this is a preliminary draft and changes are to be expected, familiarising yourself with the Work Programme will give you an early insight and strategic advantage to help shape strong, competitive proposals well before the calls are officially launched. As shown here, the draft Health Work Programme is structured around the 6 key Destinations, each targeting specific health challenges, and contains three types of calls.
This year, several call topics have the same deadline, so resources should be planned accordingly and well in advance. Hence, a closer look at the 19 call topics of the draft Health Work Programme allows us to see that there are 13 single-stage, 2 partnerships and 4 two-stage calls (for which, initially, a short proposal of ten pages first is submitted and then, once admitted to the second stage, the full proposal can be submitted).
Horizon Europe health initiatives: Our team helps you turn your ideas into projects
At accelopment, we have extensive experience in securing EU funding for research and innovation projects, with a strong track record in Horizon Europe Health projects. Our team of experts supports researchers, companies and institutions throughout the entire funding process – from strategic grant planning, to proposal writing, project management and communication and dissemination. With deep knowledge of Pillar II Health funding opportunities, we help our partners maximise their chances of success in securing European health research grants. We are currently involved in several significant health projects, including EDiHTA, EU PAL-COPD, GENEGUT and more, and look forward to supporting researchers in the upcoming calls.
Horizon Europe 2025 health call topics – key facts for you to know*
Get ready to dive into the biggest funding opportunities for health research in Horizon Europe 2025! The tables below break down the key calls by Destination, showing where the EU is investing in cutting-edge innovation, from disease prevention to AI-driven healthcare. Whether you are chasing funding for breakthrough treatments or tackling global health challenges, this is your roadmap to the next big opportunity.
Destination 1: Staying healthy in a rapidly changing society
| Call topic | Type | Budget (EUR million) | Budget/project | Deadline |
| HORIZON-HLTH-2025-03-STAYHLTH-01-two-stage: Improving the quality of life of persons with intellectual disabilities and their families | RIA | 40 | 6-8 (lump sum) | 18/09/2025 and 16/04/2026 |
Destination 2: Living and working in a health-promoting environment
| Call topic | Type | Budget (EUR million) | Budget/project | Deadline |
| HORIZON-HLTH-2025-03-ENVHLTH-01-two-stage: The impact of pollution on the development and progression of brain diseases and disorders | RIA | 40 | 6-7 (lump sum) | 18/09/2025 and 16/04/2026 |
| HORIZON-HLTH-2025-03-ENVHLTH-02-two-stage: Advancing knowledge on the impacts of micro- and nanoplastics on human health | RIA | 40 | 7-8 (lump sum) | 18/09/2025 and 16/04/2026 |
Destination 3: Tackling diseases and reducing disease burden
| Call topic | Type | Budget (EUR million) | Budget/project | Deadline |
| HORIZON-HLTH-2025-01-DISEASE-01: Testing safety and efficacy of phage therapy for the treatment of antibiotic-resistant bacterial infections | RIA | 45 | 15 (lump sum) | 18/09/2025 |
| HORIZON-HLTH-2025-03-DISEASE-02-two-stage: Advancing innovative interventions for mental, behavioural and neurodevelopmental disorders | RIA | 50 | 6-8 (lump sum) | 18/09/2025 and 16/04/2026 |
| HORIZON-HLTH-2025-01-DISEASE-03: Development of antibodies and antibody-derived proteins for the prevention and treatment of infectious diseases with epidemic potential | RIA | 50 | 10 (lump sum) | 18/09/2025 |
| HORIZON-HLTH-2025-01-DISEASE-04: Leveraging artificial intelligence for pandemic preparedness and response | RIA | 35 | 6-8 | 18/09/2025 |
| HORIZON-HLTH-2025-01-DISEASE-05: Support for the functioning of the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R) | CSA | 2 | Around 2 (lump sum) | 18/09/2025 |
| HORIZON-HLTH-2025-01-DISEASE-06: Implementation research addressing strategies to strengthen health systems for equitable high-quality care and health outcomes in the context of non-communicable diseases (GACD) | RIA | 20 | 3-4 | 18/09/2025 |
| HORIZON-HLTH-2025-02-DISEASE-01: European Partnership for Brain Health | COFUND | 150 [46 (2025), 54 (2026), 50 (2027)] | 150 | 03/06/2025 |
| HORIZON-HLTH-2025-02-DISEASE-02: European partnership fostering a European Research Area (ERA) for health research (Phase 2) | COFUND | 77 | 77 | 03/06/2025 |
Destination 4: Ensuring equal access to innovative, sustainable, and high-quality healthcare
| Call topic | Type | Budget (EUR million) | Budget/project | Deadline |
| HORIZON-HLTH-2025-01-CARE-01: End user-driven application of Generative Artificial Intelligence models in healthcare (GenAI4EU) | RIA | 40 | 15-20 | 18/09/2025 |
Destination 5: Developing and using new tools, technologies and digital solutions for a healthy society
| Call topic | Type | Budget (EUR million) | Budget/project | Deadline |
| HORIZON-HLTH-2025-01-TOOL-01: Enhancing cell therapies with genomic techniques | RIA | 50 | 8-10 | 18/09/2025 |
| HORIZON-HLTH-2025-01-TOOL-02: Advancing cell secretome-based therapies | RIA | 40 | 9-13 | 18/09/2025 |
| HORIZON-HLTH-2025-01-TOOL-03: Leveraging multimodal data to advance Generative Artificial Intelligence applicability in biomedical research (GenAI4EU) | RIA | 50 | 15-17 | 18/09/2025 |
| HORIZON-HLTH-2025-01-TOOL-05: Boosting the translation of biotech research into innovative health therapies | RIA | 80 | 4-8 | 18/09/2025 |
Destination 6: Maintaining an innovative, sustainable, and competitive EU health industry
| Call topic | Type | Budget (EUR million) | Budget/project | Deadline |
| HORIZON-HLTH-2025-01-IND-01: Optimising the manufacturing of Advanced Therapy Medicinal Products (ATMPs) | IA | 40 | 6-8 (lump sum) | 18/09/2025 |
| HORIZON-HLTH-2025-01-IND-02: Digitalisation of conformity assessment procedures of medical devices and in vitro diagnostic medical devices | CSA | 4 | Around 4 (lump sum) | 18/09/2025 |
| HORIZON-HLTH-2025-01-IND-03: Facilitating the conduct of multinational clinical studies of orphan devices and/or of highly innovative (“breakthrough”) devices | RIA | 40 | 6-8 | 18/09/2025 |
* This information has been extracted from the draft Health Work Programme available online. As its content is subject to change, accelopment cannot be held responsible for the content of this blog.
Has any of these call topics sparked your interest? Reach out to our experts now to discuss how we can support you with our services!
