Testimonial Writing a H2020 proposal is an enormous task and requires not only excellent science but also substantial experience in proposal writing. accelopment also provides useful assistance in terms of project management and communication.
Dr Ekaterine Berishvili
VANGUARD Project Coordinator,
University of Geneva, Switzerland

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VANGUARD

New Generation Cell Therapy: Bioartificial Pancreas to Cure Type 1 Diabetes

Forty million individuals worldwide suffer from type 1 diabetes. This disease is managed by insulin therapy in a vast majority of patients because of the limited accessibility of beta cell replacement therapies (pancreas or islet of Langerhans transplantation). There is an urgent need for the development of a beta cell replacement therapy that will be available to larger numbers of type 1 diabetic patients.

The VANGUARD project aims to deliver an Advanced Therapeutic Medicinal Product (ATMP) of high translational potential, with properties of increased functionality and implantability and protection from immune destruction. We will construct a bioartificial pancreas by assembling insulin-producing organoids, composed of islet cells, human amniotic epithelial cells (hAEC) and blood outgrowth endothelial cells (BOECs), into an amniotic membrane-derived hydrogel. Components of the amniotic membrane will provide extracellular matrix and mechanical protection and confer their well-defined anti-inflammatory and immunomodulatory properties to the constructs. hAECs will be genome-edited to overexpress and locally release immunomodulatory molecules (HLA-G, HLA-E, CD47 and PD-L1) and endothelial cells will enhance graft revascularization. Functionality, biocompatibility, potency and safety of the bioartificial pancreas will be assessed in vitro and in vivo by implantation in mice reconstituted with a human immune system as pre-clinical model.

The consortium consists of 6 academic institutions with leading scientists in their field, 2 SMEs and 1 NGO with expertise in ethical and social aspects of transplantation.

The ATMP delivered upon completion of the project will provide a model for rapid development of a bioartificial pancreas, utilizing “infinite” sources of insulin-producing cells (stem cell-derived, xenogeneic), and available to all type 1 diabetic patients before they develop the devastating chronic complications of the disease.

Read more about VANGUARD on Horizon, the official EU magazine for EU-funded projects: https://horizon-magazine.eu/article/lab-grown-and-do-it-yourself-two-emerging-routes-artificial-pancreas.html

Coordinator:
Université de Genève, CH

Partners:

Project




AreaEngineering
ProgrammeH2020-MSCA-ITN
Duration01.01.2020 – 31.12.2023
Budget2.17 million EUR
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We have more than 25 years of experience in FP7, Horizon 2020 and other funding programmes, from finding the best funding scheme, to proposal writing, project management and communication. accelopment has the expertise and the staff to support you from the inception of your research and innovative idea to the management of your funded project. We will be your sparring partner through all the steps including choosing the right call and funding scheme, proposal writing, the negotiation of your grant with the European Commission (EC), and maximising the impact of your R&D project. We also like to share our experience and offer several targetted training options.t for the boxes

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