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Horizon Europe’s 2026-2027 Cluster 1 Health draft Work Programme – any call topic of interest to you in 2026?


16th October 2025 at 12:27 pm



Blog series 1/18: Work Programme 2026-2027

This blog post was updated following the official release of version 4 of the CL1 2026–2027 Health Work Programme (dated 11 November 2025).

The European Commission has pre-published drafts of the Horizon Europe 2026-2027 Work Programme through its Comitology Register. With the fourth version of the draft Health Work Programme 2026 already available online, it is time to start planning resources and putting consortia together for proposal submissions next year. It’s worth remembering that these drafts remain works in progress and may be revised before their official publication, expected at the end of 2025.

According to the draft 2026–2027 Work Programme, four calls are currently planned for 2026. These will open at the latest in February 2026, following the official adoption of the work programme later in 2025.

Infographic 1: 2026 Cluster 1 Health budget distribution per call (please note that the draft Health Work Programme can be subject to change and its official publication by the EC is expected at the end of 2025)

Unlocking the future: Insights for 2026 proposal submission

The main Cluster 1 Health call HORIZON-HLTH-2026-01 (with deadline 16 April 2026) covers the six familiar Destinations and includes 17 call topics, with 68 projects expected to be funded. The remaining three calls refer to European Partnerships (see section below), adding to a total of 20 call topics and 71 expected funded projects.

Infographic 2: HORIZON-HLTH-2026-01 call deadlines + call topics/budget per destination (please note that the draft Health Work Programme can be subject to change and its official publication by the EC is expected at the end of 2025)

Horizon Europe 2026 Health call topics – key facts for you to know

Take a closer look at the HORIZON-HLTH-2026-01 call: the tables below distil everything you need to know to plan. Whether you are chasing funding for breakthrough treatments or tackling global health challenges, this is your roadmap to the next big opportunity.

TopicsType of ActionBudgets (EUR
million)
Expected EU
contribution per project (EUR
million)
Indicative number of projects expected to be funded
Opening: 10 Feb 2026
Deadline(s): 16 Apr 2026
Destination – Staying healthy in a rapidly changing society
HORIZON-HLTH-2026-01-STAYHLTH-02: Behavioural interventions as primary prevention for Non-Communicable Diseases (NCDs) among young peopleRIA20.609.00 to 10.002
HORIZON-HLTH-2026-01-STAYHLTH-03: Building public trust and outreach in the life sciencesCSA1.901.50 to 2.00 (lump sum)1
Destination – Living and working in a health-promoting environment
HORIZON-HLTH-2026-01-ENVHLTH-01:
Towards a better understanding and anticipation of the impacts of climate change on health
RIA55.007.00 to 8.00 (lump sum)7
HORIZON-HLTH-2026-01-ENVHLTH-04:
Towards climate resilient, prepared and carbon neutral populations and healthcare systems
RIA45.007.00 to 8.00  (lump sum)6
HORIZON-HLTH-2026-01-ENVHLTH-05:
Support for a multilateral initiative on climate change and health research
CSA3.00Around 3.00 (lump sum)1
Destination – Tackling diseases and reducing disease burden
HORIZON-HLTH-2026-01-DISEASE-02:
Innovative interventions to prevent the harmful effects of using digital technologies on the mental health of children and young adults
RIA44.20Around 8.006
HORIZON-HLTH-2026-01-DISEASE-03:
Advancing research on the prevention, diagnosis, and management of post-infection long-term conditions
RIA39.306.00 to 8.00 (lump sum)5
HORIZON-HLTH-2026-01-DISEASE-04:
Development of novel vaccines for viral pathogens with epidemic potential
RIA44.209.00 to 11.005
HORIZON-HLTH-2026-01-DISEASE-09:
Multisectoral approach to tackle chronic non- communicable diseases:    implementation research maximising   collaboration and coordination with  sectors and in settings beyond the healthcare system (GACD)
RIA9.83.00 to 4.00 (lump sum)3
HORIZON-HLTH-2026-01-DISEASE-11:
Understanding of sex and/or gender-specific mechanisms of cardiovascular   diseases: determinants, risk factors and pathways
RIA39.306.00 to 7.00 (lump sum)6
HORIZON-HLTH-2026-01-DISEASE-15:
Scaling up innovation in cardiovascular health
CSA1.90Around 1.90 (lump sum)1
Destination – Ensuring equal access to innovative, sustainable, and high-quality healthcare
HORIZON-HLTH-2026-01-CARE-01:  Public
procurement of innovative solutions for improving citizens’ access to healthcare through integrated or personalised approaches
PPI24.503.00 to 8.004
HORIZON-HLTH-2026-01-CARE-03:
Identifying and addressing low-value care in health and care systems
RIA38.00Around 10.004
Destination – Developing and using new tools, technologies and digital solutions for a healthy society
HORIZON-HLTH-2026-01-TOOL-03:
Integrating New Approach Methodologies (NAMs) to advance biomedical research and regulatory testing
RIA49.005.00 to 8.00 (lump sum)7
HORIZON-HLTH-2026-01-TOOL-05: Pilot actions for follow-on funding: Leveraging EU-funded collaborative research in regenerative medicineIA29.506.00 to 8.00 (lump sum)4
HORIZON-HLTH-2026-01-TOOL-06:
Support  to  European  Research   Area  (ERA) action     on     accelerating     New     Approach Methodologies (NAMs) to advance biomedical research and testing of medicinal products and medical devices
CSA2.90Around 2.90 (lump sum)1
HORIZON-HLTH-2026-01-TOOL-07: Establishing a European network of Centres of Excellence (CoEs) for Advanced Therapies Medicinal Products (ATMPs)CSA3.90Around 3.90 (lump sum)1
Destination – Maintaining an innovative, sustainable, and competitive EU health industry
HORIZON-HLTH-2026-01-IND-03:
Regulatory science to support translational development   of   patient-centred   health technologies
RIA19.604.00 to 6.00 (lump sum)4

In addition, there are three calls foreseen on Partnerships. It needs to be noted that those are not fully funded, and eligibility conditions apply with respect to the coordinator:

Horizon Europe Health initiatives: Our team helps you turn your ideas into projects

At accelopment, we have extensive experience in securing EU funding for research and innovation projects, with a strong track record in Horizon Europe Health projects. Our team of experts supports researchers, companies and institutions throughout the entire funding process – from strategic grant planning, to proposal writing, project management and communication and dissemination. With deep knowledge of Pillar II Health funding opportunities, we help our partners maximise their chances of success in securing European health research grants. We are currently involved in several significant health projects, including EDiHTA, EU PAL-COPD, GENEGUT and more, and look forward to supporting researchers in the upcoming calls.

Dr. Eva Avilla Royo
Research & Innovation Project Manager

Work Programme 2026-2027

Integrating New Approach Methodologies (NAMs) – what Horizon Europe expects from the HLTH-2026-01-TOOL-03 call topic