Testimonial Working closely with accelopment has been incredibly smooth. Their dedication to professionalism and achieving results is truly praiseworthy.
Prof. Koen Pardon
EU-PAL-COPD Project Coordinator
Vrije Universiteit Brussel, Belgium

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Evaluation of the ICLEAR-EU intervention to integrate palliative care in the treatment of people with advanced COPD and their family caregivers: An international stepped wedge cluster RCT in six European countries

Chronic Obstructive Pulmonary Disease (COPD) is a devastating life-limiting lung disease with a high personal and societal burden. Worldwide, COPD is the third leading cause of death. The symptom burden of people with COPD is as severe and burdensome as the symptom burden of people with lung COPD. While palliative care in many countries is available for people with lung COPD, palliative care and good end-of-life care for people with COPD are not well integrated into their treatment by respiratory hospital teams in Europe.

The EU PAL-COPD project is a multidisciplinary, interprofessional, international and intersectoral project aiming at evaluating the clinical and cost-effectiveness of the ICLEAR-EU intervention for people with advanced COPD in different healthcare systems in Europe.

ICLEAR-EU is a person-centred and family-centred non-pharmacological service intervention in which respiratory teams in the hospital collaborate with interdisciplinary palliative care teams and with primary care to promote shared decision-making and advance care planning, improve symptom treatment and comfort care, and prevent re-hospitalization after an exacerbation. ICLEAR-EU is based on an existing intervention developed and pilot tested in the UK.

In EU PAL-COPD, the effectiveness of ICLEAR-EU will be assessed with a stepped wedge cluster RCT in 1,224 people with advanced COPD in 18 hospitals across six European countries. It is hence the first large-scale international trial on systematic integration of palliative care in respiratory care for people with advanced COPD. EU PAL-COPD will improve the well-being and empowerment of people with COPD and their families and advance the state of the art by providing an innovative service model to the complex palliative and end-of-life care needs. User and stakeholder involvement is crucial throughout the project.

This project contributes to the UN Sustainable Development Goal (SDG) 3.

This project is currently in grant preparation with the European Commission and set to start on 1 January 2024.

Vrije Universiteit Brussel, BE


Funded Project

AreaLife Sciences
Duration01.10.2022 - 30.09.2026
Budget2.62 million euro

Communication, Dissemination, Exploitation

Your EU project and your research results are expected to have an impact on current societal challenges, Europe`s innovation capacity and competitiveness. Communication, dissemination and exploitation activities are essential in achieving these objectives. Many of these activities require specific skills such as graphic design, communication strategy development and science communication writing. We have this skill-set.



By helping researchers and companies focus on their innovations, we contribute to addressing a wide range of global challenges. This alone makes our work rewarding and exciting.

Marco Cavallaro
Research & Innovation Project Manager