Testimonial The accelopment team never sleeps. The team readily injects encouragement and motivation when enthusiasm and energy are flagging and actively applies pressure when required to raise the level of their client’s performance.
Prof. Caitriona O’Driscoll
GENEGUT Project Coordinator
University College Cork, Ireland

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GENEGUT

Oral delivery of encapsulated RNA nanotherapeutics for targeted treatment of ileal Crohn’s disease

Crohn’s disease is a non-communicable, global disease with an accelerating incidence (up to 23 per 100,000 persons/year) and annual health costs in excess of 5 billion euro in Europe. Despite advances in new immune modulators and biological treatment, up to 30% of patients become non-responders, highlighting the pressing need for novel, advanced therapies.

GENEGUT will transform treatment of ileal Crohn’s disease (CD) by developing a first-in-class oral RNA-based therapy, tackling inflammation locally in the intestinal tissue, while avoiding systemic side effects. The success of mRNA COVID-19 vaccines demonstrated the potential of RNA-based therapies; the challenge is to extend this revolutionary therapeutic modality to non-communicable diseases where RNA delivery has not been achieved, such as ileal CD.

GENEGUT will result in an oral RNA therapeutic ready for early clinical trial including coherent plans for clinical trials and regulatory submission, thus enabling rapid availability for patients.

This project contributes to the UN Sustainable Development Goals (SDGs) 3 and 9.

Coordinator:
University College Cork, IE

Partners:

Funded Project




AreaMedical Device
ProgrammeEUREKA-Eurostars 2
Duration01.10.2019 – 30.09.2021
Budget1 million euro
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Project Management



The management of your EU project requires specific skills. From submitting deliverables on the EC portal to coordinating reporting for the entire consortium, an efficient implementation of your project is work. We can support you in this task, either as a project partner (beneficiary), a service provider or a subcontractor.

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Team



At the heart of my work is a commitment to scientific innovation as a key to societal progress. I am enthusiastic about being part of projects that lay the groundwork for a better tomorrow.

Dr. Eva Avilla Royo
Research & Innovation Project Manager