Team My main goal is to relieve the scientists of their workload so that they can fully concentrate on their projects, and with our support, tackle the challenges of the future.
Jacqueline Strehler
Research & Innovation Project Manager

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CAPSTONE

Training experts in antigen processing to deliver new drug prototypes for cancer and autoimmune diseases

Current trends in immunotherapy are to develop immuno-modulatory small molecules for intracellular targets for single therapy or combination with existing treatments. CAPSTONE scientists have recently identified the key pathway of intracellular antigen processing for modulating the immune response. ERAP enzymes that generate antigenic peptides have thus emerged as promising targets for the cancer immunotherapy and autoimmune diseases treatments. Our innovative research approach based on ERAP, targets the upstream molecular events that cause these diseases.

We aim at fully understanding this pathway, deciphering the mechanisms of antigen processing dysfunctions in diseases, and developing innovative therapeutic drugs. This will provide unique opportunities for future treatment of unmet medical needs and innovative immunotherapies. CAPSTONE will thus be an excellent scientific environment to train the next generation of 15 Early Stage Researchers (ESRs) and establish an innovative cross-fertilisation between oncology and auto-immunity. Our fellows will be able to perform outstanding research at the forefront of transdisciplinary science within a high-calibre international network of academics, industries and patient associations.

CAPSTONE brings together an intersectorial and multidisciplinary group of researchers in medicinal chemistry, X-Ray crystallography, cellular biology, oncology, autoimmunity, bioanalysis, mass spectrometry imaging, formulation, systems biology, personalised medicine that will expose the ESRs to key R&D stages, from basic research to pre-clinical development. CAPSTONE will prepare the ESRs for exciting career perspectives in academia, the pharmaceutical industry, biotechnology SMEs, and provide them with scientific and transferable skills and high-value professional connections. Industrial secondments and public engagement will add to a broad skill set to ensure employability in the higher ranks of academia and industry.

Coordinator:
University of Lille, FR

Partners:

Funded Project




AreaICT
ProgrammeH2020-MSCA-ITN
Duration01.01.2018 – 31.12.2021
Budget3.96 million euro
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Training



We are happy to share our experience through transferable skills online training courses for ESRs in ongoing MSCA-ITNs. Pick and choose from six interactive, hands-on modules.

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Team



My passion is to work with highly skilled scientists and innovative thinkers from industry and academia to build solutions for a sustainable future.

Dr. Jeanette Müller
CEO