Testimonial The preparation of a H2020 proposal requires great experience and organisation skills. accelopment has been an invaluable partner in the drafting of the Train2Target proposal and its longtime experience will be essential for achieving our objectives.
Prof. Dr. Alessandra Polissi
Train2Target Project Coordinator,
University of Milano, Italy

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Train2Target

An integrated multidisciplinary approach towards a new generation of antibiotics: Targeting function and cross-talk of bacterial envelope protein machineries

Train2Target is a multidisciplinary European Training Network built to address the challenge of the discovery of alternative antimicrobials. Innovative strategies to deliver the next generation of drugs are urgently needed. The alarming threats and spread of multi-drug resistant bacteria is currently leaving clinicians with very limited options to combat infections especially those from Gram-negative pathogens.

The Train 2Target research programme focuses on the assembly of the well-known bacterial cell envelope from a new perspective. Indeed it aims to inhibit novel targets in envelope biogenesis by altering the function and misbalancing the coordination of envelope assembly machines, which build and assemble the Gram-negative bacterial envelope. A wide variety of chemical classes and compounds sources will be screened using innovative biochemical, biophysical and genetic assays to identify valuable hit scaffolds to be optimized into druggable leads.

The high quality and credibility of our consortium are ensured by a strong interdisciplinary academia-industry partnership to encompass different complementary expertise ranging from microbiology, bacterial genetics, biochemistry, cell imaging, structural biology, biophysics and chemical synthesis. Our 9 academic groups are all renowned leaders in the cell envelope biogenesis field, whereas the complementary 5 SMEs and 3 Industry partners are specialised in drug discovery and development of novel anti-infective drugs. This unique combination of scientific excellence and industrial know-how in drug discovery covers the entire process from the design to the implementation of innovative antibacterial strategies and lead identification.

Train2Target also represents a unique research platform to train 15 Early Stage Researchers and equip them with the necessary scientific and transferable skills that will make them highly competitive for both top European research institutions and the pharma/biotech job market.

Coordinator:
Università degli Studi di Milano, IT

Partners:

Project




AreaEnergy
ProgrammeFCH-JU
Duration01.01.2011 – 31.12.2013
Budget4.1 million euro
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Project Management



The management of your EU project requires specific skills. From submitting deliverables on the EC portal to coordinating reporting for the entire consortium, an efficient implementation of your project is work. We can support you in this task, either as a project partner (Beneficiary), a service provider or a subcontractor.

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Team



ESRs in Train2Target are extremely creative and motivated. Check out their Science Slams videos on the project website.

Géraldine Messmer
Project Associate Communications