HORIZON Pillar Cluster 1 (Health) Work Programme 2025 just pre-published
29th April 2025 at 10:23 am
Last Friday, the European Commission released the pre-published versions of the Horizon Europe 2025 Work Programmes, marking an important milestone for researchers, innovators and stakeholders across Europe. We have taken the time to compare this document with the previous draft and are happy to highlight the main changes for you. Notably and also shown below, the most relevant change is that the deadline for single-stage and stage-1 of two-stage call topics will be 16 September 2025 and not 18 September 2025, as stated in the earlier draft Work Programme.
| Draft version (December 2024) | Pre-published Work Programme 2025 (April 2025) | Change |
| Single stage and stage-1 deadline: 18/09/2025 | Single stage and stage-1 deadline: 16/09/2025 | Change of deadline |
| HORIZON-HLTH-2025-03-IND-01 | HORIZON-HLTH-2025-03-IND-03-two stage | This call topic is now two-stage and lump sum |
| Call topic non-existing | HORIZON-HLTH-2025-01-DISEASE-07: Tackling high-burden for patients and under-researched medical conditions | This call topic has been added (budget: €30 million) |
| HORIZON-HLTH-2025-02-DISEASE-01 budget for 2025: 46 million euro | HORIZON-HLTH-2025-02-DISEASE-01 budget for 2025: 56.50 million euro | Budget increased by 10.5 million euro |
| Total budget: 789 million euro | Total budget: 829.5 million euro | Total budget increased by 40.5 million euro |
Horizon Europe 2025 health call topics from the pre-published Work Programmes
Our new infographic offers a quick overview of the expected number of projects to be funded under the Horizon Europe 2025 Health Work Programme, alongside a breakdown of the available budget per destination. It highlights where the biggest funding opportunities lie, helping you to spot high-potential calls and plan your proposals strategically.
The tables below break down the key calls by Destination, showing where the EU is investing in cutting-edge innovation to advance personalised medicine, strengthen health systems, address environmental impacts on health, and support the development of innovative health technologies and treatments. From groundbreaking research to transformative health solutions, this is your guide to the next big win.
| Destination 1: Staying healthy in a rapidly changing society | ||||
| Call topic | Type of Action | Budget (EUR million) | Budget/ project | Deadline |
| HORIZON-HLTH-2025-03-STAYHLTH-01-two-stage: Improving the quality of life of persons with intellectual disabilities and their families | RIA | 40 | 6-8 (lump sum) | 16/09/2025 and 16/04/2026 |
| Destination 2: Living and working in a health-promoting environment | ||||
| Call topic | Type of Action | Budget (EUR million) | Budget/ project | Deadline |
| HORIZON-HLTH-2025-03-ENVHLTH-01-two-stage: The impact of pollution on the development and progression of brain diseases and disorders | RIA | 40 | 6-7 (lump sum) | 16/09/2025 and 16/04/2026 |
| HORIZON-HLTH-2025-03-ENVHLTH-02-two-stage: Advancing knowledge on the impacts of micro- and nanoplastics on human health | RIA | 40 | 7-8 (lump sum) | 16/09/2025 and 16/04/2026 |
| Destination 3: Tackling diseases and reducing disease burden | |||||
| Call topic | Type of Action | Budget (EUR million) | Budget/ project | Deadline | |
| HORIZON-HLTH-2025-01-DISEASE-01: Testing safety and efficacy of phage therapy for the treatment of antibiotic-resistant bacterial infections | RIA | 45 | 15 (lump sum) | 16/09/2025 | |
| HORIZON-HLTH-2025-03-DISEASE-02-two-stage: Advancing innovative interventions for mental, behavioural and neurodevelopmental disorders | RIA | 50 | 6-8 (lump sum) | 16/09/2025 and 16/04/2026 | |
| HORIZON-HLTH-2025-01-DISEASE-03: Development of antibodies and antibody-derived proteins for the prevention and treatment of infectious diseases with epidemic potential | RIA | 50 | 10 (lump sum) | 16/09/2025 | |
| HORIZON-HLTH-2025-01-DISEASE-04: Leveraging artificial intelligence for pandemic preparedness and response | RIA | 35 | 6-8 | 16/09/2025 | |
| HORIZON-HLTH-2025-01-DISEASE-05: Support for the functioning of the Global Research Collaboration for Infectious Disease Preparedness (GloPID-R) | CSA | 2 | Around 2 (lump sum) | 16/09/2025 | |
| HORIZON-HLTH-2025-01-DISEASE-06: Implementation research addressing strategies to strengthen health systems for equitable high-quality care and health outcomes in the context of non-communicable diseases (GACD) | RIA | 20 | 3-4 | 16/09/2025 | |
| HORIZON-HLTH-2025-01-DISEASE-07: Tackling high-burden for patients and under-researched medical conditions | RIA | 30 | Around 6 | 16/09/2025 | |
| HORIZON-HLTH-2025-02-DISEASE-01: European Partnership for Brain Health | COFUND | 150 [56.50 (2025), 46.5 (2026), 47 (2027)] | 150 | 03/06/2025 | |
| HORIZON-HLTH-2025-02-DISEASE-02: European partnership fostering a European Research Area (ERA) for health research (Phase 2) | COFUND | 77 | 77 | 03/06/2025 | |
| Destination 4: Ensuring equal access to innovative, sustainable, and high-quality healthcare | ||||
| Call topic | Type of Action | Budget (EUR million) | Budget/ project | Deadline |
| HORIZON-HLTH-2025-01-CARE-01: End user-driven application of Generative Artificial Intelligence models in healthcare (GenAI4EU) | RIA | 40 | 15-20 | 16/09/2025 |
| Destination 5: Developing and using new tools, technologies and digital solutions for a healthy society | ||||
| Call topic | Type of Action | Budget (EUR million) | Budget/ project | Deadline |
| HORIZON-HLTH-2025-01-TOOL-01: Enhancing cell therapies with genomic techniques | RIA | 50 | 8-10 | 16/09/2025 |
| HORIZON-HLTH-2025-01-TOOL-02: Advancing cell secretome-based therapies | RIA | 40 | 9-13 | 16/09/2025 |
| HORIZON-HLTH-2025-01-TOOL-03: Leveraging multimodal data to advance Generative Artificial Intelligence applicability in biomedical research (GenAI4EU) | RIA | 50 | 15-17 | 16/09/2025 |
| HORIZON-HLTH-2025-01-TOOL-05: Boosting the translation of biotech research into innovative health therapies | RIA | 80 | 4-8 | 16/09/2025 |
| Destination 6: Maintaining an innovative, sustainable, and competitive EU health industry | ||||
| Call topic | Type of Action | Budget (EUR million) | Budget/ project | Deadline |
| HORIZON-HLTH-2025-01-IND-01: Optimising the manufacturing of Advanced Therapy Medicinal Products (ATMPs) | IA | 40 | 6-8 (lump sum) | 16/09/2025 |
| HORIZON-HLTH-2025-01-IND-02: Digitalisation of conformity assessment procedures of medical devices and in vitro diagnostic medical devices | CSA | 4 | Around 4 (lump sum) | 16/09/2025 |
| HORIZON-HLTH-2025-03-IND-03-two stage: Facilitating the conduct of multinational clinical studies of orphan devices and/or of highly innovative (“breakthrough”) devices | RIA | 40 | 6-8 (lump sum) | 16/09/2025 and 16/04/2026 |
* This information has been extracted from the pre-published Health Work Programmes.
The adoption of the Horizon Europe ‘main’ work programme 2025 and the amended Horizon Europe ‘main’ work programme 2023-2025 is planned for May 2025.
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Since our foundation, we have been collaborating with more than 1,000 organisations in Europe and beyond. Our successful Research and Innovation Actions (RIAs and IAs) in Health include the recently started Horizon Europe Cluster 1 project EXPOSIM and several other HORIZON projects EDiHTA, EU PAL-COPD, GLIOMATCH, COVend, GENEGUT and MyPath. Our Horizon 2020 health projects are still going strong, including AI-Mind, EXIMIOUS and VANGUARD, and many health-focused Innovative Training and Doctoral Networks, including CAPSTONE, MITGEST and MobiliTraIN.
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